Not everyone wants a weekly injection. For a long time, the GLP-1 medications for chronic weight management were all given as weekly shots — but there is now an FDA-approved option you take as a once-daily pill: Foundayo (orforglipron).
A pill instead of a weekly shot
Foundayo's active ingredient, orforglipron, is a small molecule rather than a peptide, so it works as an oral tablet instead of an injection. For people who are needle-averse — or who just want something simpler — that is the whole appeal. It was FDA-approved for chronic weight management in 2026.
In its registrational trial, as an adjunct to a reduced-calorie diet and increased physical activity, orforglipron at the highest studied dose produced an average of up to 12.4% of body weight at 72 weeks (ATTAIN-1). That is the medicine's own clinical-trial result, not a promise — individual results vary, and no result is guaranteed.
What about the injectable options?
The compounded GLP-1s OS Reboot offers — semaglutide and tirzepatide — are injections, used for physician-evaluated metabolic support (not FDA-approved, and not a copy of an FDA-approved drug). The branded injectables Wegovy and Zepbound are FDA-approved for chronic weight management. A licensed physician helps decide whether a pill or an injection fits you.
What the pill costs
Foundayo is from $436/month at OS Reboot — no membership fee, 10% off a first order for new patients, and you are charged only if a physician approves treatment.
See the Foundayo program → · Foundayo pricing explained
Educational information, not medical advice, a diagnosis, or a prescription. Foundayo is available only by prescription after a licensed physician's review. OS Reboot does not practice medicine or operate a pharmacy.